Fibrinogen supplementationIn severe trauma patients, it is crucial to receive rapid information on the patient’s current coagulation status. The first ROTEM or TEG test results are Cyclohept-2-enone available within minutes [30]. Low maximum clot firmness (MCF) in EXTEM, INTEM and FIBTEM or maximum amplitude (MA, the equivalent TEG parameter) has been identified as an important determinant of RBC transfusion [23,30,63-67]. In one study, MA but not standard coagulation tests (INR, PT, aPTT) was predictive for blood product transfusions [66]. Leemann et al. showed that low INTEM MCF and low haemoglobin levels were independent risk factors for MT [63]. TEG clot strength (G) on admission to the ER has been reported to provide consistent prediction of MT in trauma patients [65]. Davenport et al. observed thatFibrinogen seems to reach critically low levels very early after trauma [9,13,23,30]. Current European guidelines recommend a plasma fibrinogen concentration in trauma patients of no less than 1.5-2.0 g/L [29]. However, there is limited evidence that fibrinogen administration improves outcomes in trauma patients. A retrospective military study reported increased survival among patients receiving a high fibrinogen:RBC ratio (0.48 g fibrinogen per unit of RBCs), compared with those receiving a lower ratio (0.1 g fibrinogen per unit of RBC) [68]. FFP is one potential source of fibrinogen, but it is collected from healthy volunteers who may occasionally have low fibrinogen levels. Fibrinogen concentrations of 2 g/L have been found in both FFP and solvent-detergent (SD) plasma [69]. Chowdhury et al. compared changes in coagulation factor levels after FFP transfusion of 12 mL/kg bodyweight or 35 mL/kg bodyweight, and observed a substantial increase in fibrinogen solely 54718-39-7 chemscene,39065-95-7 chemscene,2454396-80-4 Formula,503614-91-3 Formula,1088994-18-6 Documentation,2168499-15-6 supplier,2137792-51-7 custom synthesis,52222-73-8 supplier,944401-77-8 supplier,142266-62-4 Building Blocks,55860-35-0 chemscene,10325-70-9 web,15450-69-8 custom synthesis,73246-45-4 site,945244-29-1 Building Blocks,13323-45-0 site,89003-95-2 Order Online,784-71-4 custom synthesis,78775-11-8 web,25563-04-6 manufacturer,17145-91-4 Documentation,1416013-62-1 Description,20955-94-6 Formula,57196-62-0 MS,20357-21-5 custom synthesis,10542-80-0 custom synthesis,32305-98-9 custom synthesis,7209-11-2 Building Blocks,90259-31-7 manufacturer,56962-10-8 Documentation,100523-84-0 site,574007-66-2 Formula,926922-40-9 Purity ¡۳30%,57097-81-1 custom synthesis,124276-67-1 supplier,869970-25-2 manufacturer,376584-63-3 manufacturer,40235-68-5 In Stock,96034-64-9 NMR,849052-26-2 custom synthesis,49764-63-8 Description,685517-71-9 NMR,142946-79-0 Documentation,194-59-2 Order Online,79424-03-6 custom synthesis,3307-41-3 Technical Information,790667-49-1 Order Online,1073-39-8 site,145038-49-9 manufacturer,201940-08-1 web,666832-71-9 supplier,219873-06-0 Formula,57645-53-1 manufacturer,58640-01-0 Formula,37901-92-1 web,1162120-35-5 Description,612501-45-8 Formula,761440-16-8 supplier,689291-89-2 custom synthesis,113231-05-3 Documentation,42779-56-6 Documentation,866807-26-3 chemscene,939410-87-4 Data Sheet,169869-90-3 manufacturer,76137-53-6 Formula,402-50-6 NMR,1889077-30-8 HPLC,253315-11-6 Formula,1221448-62-9 supplier,886501-15-1 site,875781-43-4 Purity ¡۱43%,5521-31-3 Data Sheet,2278357-65-4 Formula,81721-86-0 Building Blocks,14295-52-4 custom synthesis,191604-81-6 Documentation,328086-60-8 Documentation,29046-78-4 custom synthesis,6783-05-7 Documentation,67460-86-0 Data Sheet,108549-23-1 MS,363166-11-4 Documentation,12135-22-7 Description,1672665-55-2 chemscene,63600-35-1 Building Blocks,40153-45-5 Documentation,24566-79-8 manufacturer,886365-02-2 supplier,16545-68-9 web,73799-64-1 Documentation,58546-89-7 Documentation,106291-80-9 Description,1137869-92-1 Order Online,50741-70-3 HPLC,213764-25-1 Description,65326-33-2 custom synthesis,1573-91-7 Building Blocks,50413-30-4 Description,857530-80-4 Documentation,177284-56-9 supplier,904326-92-7 Technical Information,33689-29-1 manufacturer,153747-97-8 web,59854-12-5 Order Online,2569698-42-4 manufacturer,28824-91-1 MS,1194-18-9 Formula,151049-87-5 manufacturer,3999-55-1 Data Sheet,800402-06-6 supplier,10597-60-1 Description,16079-88-2 web,79080-39-0 Formula,106778-43-2 Description,887144-94-7 Formula,197223-39-5 Technical Information,1002309-52-5 Technical Information,1236861-75-8 Technical Information,1107627-02-0 NMR,72607-53-5 web,1345469-26-2 Purity ¡۱93%,98905-05-6 custom synthesis,60239-18-1 Documentation,406913-93-7 Documentation,51043-72-2 NMR,13885-13-7 Technical Information,63024-50-0 Technical Information,2840-44-0 supplier,4956-05-2 manufacturer,83647-40-9 Order Online,89985-87-5 site,288-42-6 Data Sheet,120157-95-1 In Stock,64700-65-8 web,1205-58-9 Formula,1140908-89-9 In Stock,405939-39-1 Purity ¡۲09%,103440-70-6 Purity ¡۲10%,873055-55-1 Data Sheet,52798-01-3 Formula,2533-67-7 Technical Information,1026089-09-7 Data Sheet,3441-01-8 Order Online,1072951-50-8 custom synthesis,2968-13-0 Formula,160590-40-9 Formula,5836-54-4 Order Online,13831-03-3 Formula,10328-92-4 Description,52378-64-0 Data Sheet,548-93-6 Technical Information,1037834-62-0 custom synthesis,30169-25-6 HPLC,59260-76-3 Formula,1798-85-2 chemscene,142356-33-0 In Stock,850429-64-0 Formula,681807-59-0 manufacturer,2055761-19-6 Description,766-46-1 Documentation,58196-33-1 web,391624-46-7 Technical Information,138373-85-0 supplier,438631-77-7 Purity ¡۲36%,135716-08-4 Building Blocks,99329-85-8 Formula,4233-33-4 Technical Information,13965-03-2 Formula,3816-62-4 Formula,75833-38-4 Building Blocks,54258-41-2 Documentation,146394-99-2 supplier,14062-05-6 web,2031242-60-9 HPLC,68797-61-5 Technical Information,55704-60-4 manufacturer,942919-26-8 web,406470-63-1 Technical Information,43192-34-3 HPLC,4664-08-8 Technical Information,1209167-05-4 Data Sheet,403-18-9 manufacturer,22262-60-8 chemscene,1126-44-9 Formula,774234-25-2 Description,507472-25-5 Data Sheet,117342-20-8 Formula,878376-35-3 site,107504-07-4 NMR,45206-91-5 Formula,2133-07-5 Data Sheet,90633-29-7 Technical Information,141699-57-2 web,741721-51-7 Data Sheet,83947-59-5 manufacturer,2605-68-7 Building Blocks,500357-40-4 web,1119505-52-0 Description,188447-91-8 Building Blocks,260430-93-1 Technical Information,56961-78-5 custom synthesis,199110-64-0 Technical Information,13482-23-0 Formula,1345091-18-0 Technical Information,133261-06-0 Documentation,1072150-21-0 custom synthesis,2196-99-8 site,6999-03-7 Data Sheet,913836-22-3 Data Sheet,933469-83-1 Documentation,30830-27-4 In Stock,16689-35-3 custom synthesis,121138-01-0 custom synthesis,451459-17-9 Technical Information,1109-15-5 Description,79055-60-0 Description,39891-04-8 Building Blocks,163619-04-3 Formula,66346-87-0 Description,128-63-2 Description,289038-22-8 Description,28314-83-2 Purity ¡۲94%,208173-21-1 chemscene,50606-31-0 chemscene,1374264-44-4 site,944900-49-6 In Stock,1122-43-6 chemscene,892570-95-5 web,109704-53-2 Data Sheet,51364-51-3 Description,195202-09-6 Formula,827-33-8 Description,1829-32-9 chemscene,223259-62-9 supplier,124289-21-0 manufacturer,1415564-71-4 Data Sheet,406232-79-9 Documentation,5194-32-1 supplier,18720-35-9 Description,36748-89-7 Data Sheet,24346-56-3 Technical Information,656-46-2 site,2156-04-9 web,5870-38-2 supplier,7597-56-0 Documentation,73365-02-3 Description,89581-38-4 Documentation,39513-26-3 web,22532-61-2 Order Online,51939-71-0 Documentation,33398-79-7 chemscene,3177-20-6 Technical Information,705-28-2 web,22724-81-8 Documentation,15484-46-5 Technical Information,223259-63-0 chemscene,1314538-55-0 MS,5994-87-6 Purity ¡۳55%,404-24-0 Data Sheet,4298-52-6 HPLC,95058-81-4 Purity ¡۳58%,14160-91-9 custom synthesis,1013883-02-7 supplier,175205-81-9 NMR,79537-70-5 web,935-30-8 Building Blocks,731011-86-2 Technical Information,144120-54-7 supplier,199174-24-8 custom synthesis,2417920-98-8 Description,41428-22-2 HPLC,150629-67-7 web,269410-24-4 web,124755-24-4 Documentation,20744-39-2 manufacturer,74003-55-7 manufacturer,567-61-3 custom synthesis,5551-11-1 Technical Information,1044707-17-6 In Stock,40004-08-8 Formula,14446-24-3 Description,38707-70-9 manufacturer,703-91-3 Documentation,1099029-85-2 Building Blocks,75416-51-2 supplier,62247-22-7 Technical Information,284492-23-5 Description,288148-34-5 Technical Information,252932-49-3 Technical Information,5406-18-8 Formula,35979-69-2 Data Sheet,30725-00-9 Formula,120116-88-3 supplier,16063-69-7 Description,14548-51-7 web,103260-65-7 custom synthesis,94333-62-7 Documentation,365564-05-2 web,50488-34-1 site,1208081-25-7 custom synthesis,1206675-01-5 Technical Information,133803-81-3 Documentation,14544-47-9 NMR,532-12-7 Description,29509-06-6 chemscene,34403-48-0 Building Blocks,351410-62-3 Technical Information,53312-77-9 site,36805-97-7 MS,6030-36-0 web,59279-58-2 Documentation,39773-47-2 custom synthesis,1805818-57-8 site,1251032-65-1 Data Sheet,6140-65-4 manufacturer,67963-68-2 Data Sheet,164334-69-4 Documentation,191348-14-8 Building Blocks,1234616-13-7 Technical Information,1185100-09-7 web,13288-57-8 Documentation,1532-84-9 Documentation,41252-98-6 manufacturer,1137869-93-2 Documentation,28148-04-1 supplier,2589-12-0 custom synthesis,13999-39-8 Technical Information,947-91-1 chemscene,74420-02-3 Data Sheet,17996-12-2 Building Blocks,117324-58-0 manufacturer,13991-08-7 chemscene,500556-91-2 Technical Information,17997-47-6 Documentation,607373-83-1 web,1206979-33-0 site,28945-98-4 Formula,104-11-0 chemscene,5462-71-5 In Stock,1147557-97-8 MS,111409-79-1 Technical Information,10165-86-3 Technical Information,50868-73-0 Documentation,934-98-5 chemscene,40353-34-2 web,1683-85-8 Formula,3189-22-8 Purity ¡۴19%,329976-73-0 NMR,188813-04-9 custom synthesis,107259-05-2 Data Sheet,1196156-59-8 Description,135-67-1 manufacturer,142070-24-4 Data Sheet,2172466-50-9 MS,145508-94-7 Formula,37418-88-5 Documentation,864293-44-7 NMR,190906-92-4 Order Online,10049-08-8 custom synthesis,936250-20-3 Documentation,34699-28-0 MS,161417-28-3 custom synthesis,29836-26-8 Documentation,2945-08-6 Building Blocks,1122-10-7 site,95464-05-4 custom synthesis,89641-18-9 chemscene,1420800-30-1 Data Sheet,4295-06-1 Description,73505-48-3 supplier,1196153-47-5 Technical Information,66176-17-8 custom synthesis,97456-81-0 Data Sheet,112641-20-0 Documentation,51644-96-3 Documentation,78560-45-9 MS,321970-60-9 Purity ¡۴49%,1225049-48-8 chemscene,131341-86-1 custom synthesis,38186-51-5 Documentation,1236862-38-6 chemscene,143655-70-3 Documentation,82769-76-4 Building Blocks,446-29-7 Order Online,885520-35-4 Documentation,53207-00-4 MS,1167055-92-6 In Stock,62803-47-8 In Stock,4694-91-1 Documentation,3975-77-7 site,845866-85-5 Building Blocks,1076-96-6 Building Blocks,59379-02-1 supplier,252989-57-4 Order Online,160590-36-3 manufacturer,155975-19-2 Data Sheet,884495-13-0 In Stock,29027-17-6 Documentation,1172052-59-3 Building Blocks,335104-84-2 site,170098-98-3 chemscene,248274-16-0 Technical Information,23235-01-0 Data Sheet,120155-43-3 manufacturer,685109-10-8 Data Sheet,193290-80-1 Data Sheet,74346-19-3 supplier,4971-18-0 Description,10602-00-3 Technical Information,108612-54-0 Technical Information,913835-76-4 custom synthesis,176707-77-0 web,6287-82-7 Technical Information,193290-19-6 Data Sheet,194543-22-1 NMR,21962-45-8 manufacturer,99027-90-4 chemscene,884494-49-9 MS,101251-09-6 Order Online,392331-89-4 manufacturer,81270-37-3 web,2055119-43-0 custom synthesis,131328-27-3 NMR,688810-12-0 supplier,717843-51-1 site,1628263-61-5 Purity ¡۴98%,34301-54-7 Data Sheet,2350-89-2 Building Blocks,503-66-2 Technical Information,85920-63-4 Technical Information,19256-31-6 Description,53439-88-6 Technical Information,590371-58-7 Data Sheet,10167-97-2 supplier,677728-92-6 site,96517-92-9 site,63697-96-1 Order Online,1172713-86-8 Technical Information,13991-36-1 web,3027-05-2 chemscene,2835-97-4 manufacturer,3298-16-6 custom synthesis,7648-30-8 supplier,83265-53-6 Building Blocks,1093860-48-0 web,80657-57-4 Description,81090-53-1 Building Blocks,3819-88-3 Building Blocks,1092443-98-5 Technical Information,140645-24-5 Technical Information,57190-17-7 Description,811-93-8 Order Online,54745-74-3 MS,14190-59-1 NMR,2879-42-7 Documentation,162607-19-4 Technical Information,39639-99-1 site,198835-04-0 Documentation,144120-53-6 custom synthesis,1886994-07-5 Purity ¡۵32%,127828-22-2 manufacturer,89043-32-3 Data Sheet,57500-81-9 Technical Information,2152673-80-6 Documentation,111627-46-4 Formula,234108-73-7 Order Online,23082-30-6 supplier,361-72-8 supplier,148-79-8 Building Blocks,7651-82-3 chemscene,22245-84-7 Documentation,39069-02-8 supplier,851386-31-7 Formula,213771-32-5 In Stock,6018-56-0 In Stock,2713-29-3 custom synthesis,4293-57-6 Formula,69626-39-7 site,77278-70-7 Formula,865815-09-4 Technical Information,39512-59-9 Documentation,130047-19-7 Documentation,885223-65-4 supplier,1394003-86-1 Documentation,876919-08-3 web,944805-63-4 Documentation,24630-67-9 Building Blocks,92-89-7 Order Online,131747-41-6 custom synthesis,329794-28-7 Technical Information,957062-84-9 Data Sheet,361550-43-8 Building Blocks,95408-45-0 manufacturer,50-23-7 site,57489-77-7 web,790667-43-5 Technical Information,7022-37-9 Description,3398-22-9 Documentation,3093-97-8 Technical Information,1075242-43-1 site,363-58-6 Documentation,144701-24-6 web,67198-21-4 Documentation,53985-49-2 Building Blocks,32936-76-8 web,1261468-33-0 In Stock,121859-57-2 Technical Information,886762-71-6 site,173405-78-2 Documentation,78018-17-4 Data Sheet,4265-16-1 Technical Information,62458-96-2 custom synthesis,155797-02-7 supplier,157141-27-0 Formula,17396-35-9 site,162155-38-6 supplier,16292-95-8 custom synthesis,623580-02-9 Documentation,17827-60-0 chemscene,56842-95-6 chemscene,42097-42-7 Description,16502-01-5 chemscene,1154741-20-4 Purity ¡۶20%,1394040-59-5 Technical Information,126689-00-7 Purity ¡۶22%,49674-16-0 chemscene,1427082-83-4 chemscene,1003709-39-4 site,32337-96-5 chemscene,75680-92-1 Technical Information,84575-27-9 manufacturer,76315-33-8 Technical Information,4864-01-1 custom synthesis,136725-55-8 Documentation,17321-29-8 Data Sheet,1020174-04-2 In Stock,1394042-40-0 Formula,159277-47-1 HPLC,27825-20-3 manufacturer,375853-98-8 Documentation,934758-27-7 supplier,3712-40-1 custom synthesis,282735-66-4 site,55864-87-4 chemscene,713141-12-9 chemscene,52462-29-0 manufacturer,19064-65-4 Technical Information,63485-50-7 site,90564-77-5 Documentation,98436-83-0 chemscene,59760-01-9 site,305790-48-1 Description,1016234-87-9 manufacturer,175278-30-5 site,175276-74-1 Documentation,957034-45-6 Formula,25813-25-6 Building Blocks,139551-74-9 manufacturer,151945-84-5 Documentation,27298-98-2 site,19788-36-4 site,25016-02-8 Documentation,17376-63-5 Building Blocks,21382-98-9 web,762260-64-0 Building Blocks,148639-07-0 Purity ¡۶38%,651027-01-9 Technical Information,144599-95-1 chemscene,19112-35-7 Order Online,17345-77-6 site,91229-86-6 custom synthesis,26893-68-5 Technical Information,1864073-05-1 custom synthesis,1128-61-6 site,938043-30-2 Documentation,1627924-18-8 site,1229603-46-6 Technical Information,936841-70-2 site,52670-38-9 chemscene,867366-91-4 Purity ¡۶52%,6940-57-4 Description,1703-61-3 custom synthesis,100421-52-1 site,123973-22-8 site,95201-93-7 Technical Information,198561-07-8 manufacturer,5400-79-3 Data Sheet,19005-93-7 Description,939400-34-7 custom synthesis,120740-08-1 Formula,3096-81-9 chemscene,893441-85-5 site,35511-15-0 MS,34914-36-8 In Stock,178876-83-0 Description,72287-26-4 web,16681-56-4 Building Blocks,160233-76-1 chemscene,2040-14-4 Documentation,41059-02-3 Formula,1219956-23-6 Documentation,1269232-95-2 Technical Information,204376-48-7 Order Online,1776-37-0 Documentation,1247924-89-5 custom synthesis,116557-46-1 Description,120121-01-9 Technical Information,84547-62-6 Technical Information,20442-79-9 site,90-52-8 Documentation,23012-13-7 custom synthesis,2097971-11-2 Data Sheet,116286-81-8 Technical Information,105-84-0 custom synthesis,20327-23-5 HPLC,112776-84-8 Formula,5470-65-5 Data Sheet,21548-73-2 Documentation,1005612-69-0 custom synthesis,1049756-13-9 Documentation,74173-58-3 Technical Information,14898-67-0 HPLC,873924-08-4 HPLC,5617-70-9 Description,134098-70-7 site,73208-82-9 web,40319-63-9 Documentation,1352244-77-9 supplier,505084-59-3 Documentation,72080-83-2 manufacturer,19271-24-0 Documentation,256417-10-4 Description,19282-44-1 Technical Information,251115-21-6 Description,614-98-2 supplier,108915-04-4 Technical Information,648921-37-3 Formula,1001020-14-9 manufacturer,885267-36-7 chemscene,70708-33-7 chemscene,6790-09-6 chemscene,18370-95-1 Purity ¡۷14%,2221-00-3 web,690632-39-4 manufacturer,62366-58-9 Description,2353-33-5 supplier,10201-71-5 NMR,160357-94-8 supplier,536-25-4 supplier,533-30-2 Documentation,151103-08-1 Data Sheet,7770-45-8 chemscene,1179042-36-4 chemscene,82475-76-1 Building Blocks,1384433-82-2 Description,1170249-44-1 Description,42163-27-9 Technical Information,18531-95-8 manufacturer,7170-01-6 web,51586-21-1 Formula,120100-15-4 Formula,3650-78-0 manufacturer,211943-27-0 Description,66200-70-2 web,1181458-90-1 Technical Information,5394-13-8 Formula,928664-98-6 HPLC,178033-78-8 Purity ¡۷40%,16605-99-5 MS,2270-59-9 custom synthesis,144222-34-4 Data Sheet,16732-69-7 Order Online,1219827-56-1 chemscene,24566-81-2 web,166815-96-9 Technical Information,1158319-57-3 custom synthesis,2621939-48-6 Documentation,1240518-54-0 supplier,13047-01-3 Data Sheet,2439-04-5 Documentation,145691-59-4 manufacturer,262433-22-7 web,479622-36-1 web,5579-66-8 manufacturer,24310-15-4 Technical Information,6315-60-2 custom synthesis,95756-62-0 Technical Information,255724-71-1 Purity ¡۷60%,156017-42-4 Formula,7470-38-4 manufacturer,2380-84-9 manufacturer,159610-89-6 Documentation,103977-78-2 custom synthesis,18595-17-0 site,1048960-62-8 Order Online,3945-85-5 NMR,828298-11-9 Documentation,2475-81-2 HPLC,223137-87-9 site,1159908-24-3 supplier,1190315-72-0 Documentation,799773-82-3 web,91978-81-3 Documentation,129012-04-0 Technical Information,935-14-8 supplier,277756-45-3 Building Blocks,13362-78-2 web,19171-19-8 manufacturer,7238-61-1 chemscene,115306-75-7 HPLC,68500-37-8 Description,6942-58-1 Data Sheet,1094070-77-5 custom synthesis,75705-21-4 Building Blocks,281192-91-4 custom synthesis,92933-47-6 site,172899-78-4 Description,42826-42-6 Technical Information,83728-40-9 custom synthesis,115994-87-1 web,6854-07-5 Technical Information,42881-66-3 site,114873-11-9 Technical Information,82972-28-9 Documentation,932-35-4 Data Sheet,20274-69-5 NMR,550363-85-4 supplier,1030377-21-9 supplier,89584-24-7 Order Online,6921-22-8 custom synthesis,136888-20-5 manufacturer,2003-10-3 Data Sheet,5751-48-4 NMR,59804-25-0 HPLC,889865-56-9 Data Sheet,77128-72-4 manufacturer,234108-42-0 custom synthesis,41070-35-3 web,59608-97-8 Formula,177596-38-2 HPLC,1006348-65-7 Documentation,36745-93-4 Description,886496-45-3 Formula,447464-03-1 Documentation,56267-48-2 Documentation,1497312-94-3 supplier,139009-66-8 web,20734-76-3 Order Online,35852-77-8 manufacturer,37674-72-9 Data Sheet,280774-03-0 supplier,25045-36-7 Purity ¡۸49%,2044901-46-2 Building Blocks,103-40-2 Formula,4704-94-3 manufacturer,34631-53-3 custom synthesis,17205-02-6 Technical Information,15448-77-8 manufacturer,214210-21-6 Data Sheet,162894-76-0 HPLC,373384-18-0 supplier,285984-25-0 Documentation,2096331-76-7 Documentation,1396680-55-9 custom synthesis,886886-04-0 supplier,1024583-33-2 Technical Information,5959-52-4 Formula,1121-66-0 supplier,657-24-9 Technical Information,5198-88-9 Technical Information,361476-01-9 web,1150617-92-7 Order Online,6267-02-3 chemscene,14245-62-6 custom synthesis,28562-68-7 Documentation,603965-77-1 web,19520-74-2 Purity ¡۱074%,2138-22-9 Formula,669050-70-8 MS,1416881-52-1 NMR,601-84-3 custom synthesis,517920-69-3 Documentation,18791-99-6 Data Sheet,14542-12-2 custom synthesis,85462-59-5 Data Sheet,41574-91-8 Formula,76543-27-6 supplier,828-94-4 Technical Information,56962-11-9 custom synthesis,23077-43-2 Documentation,590-97-6 Purity ¡۱088%,1201-91-8 Formula,72715-12-9 site,887919-35-9 supplier,26095-36-3 custom synthesis,1227068-67-8 manufacturer,866633-25-2 NMR,151159-28-3 site,66522-66-5 chemscene,3526-43-0 chemscene,428-63-7 Documentation,93281-65-3 Documentation,15029-36-4 chemscene,1824063-21-9 Formula,446299-81-6 chemscene,20776-55-0 Building Blocks,181365-26-4 Order Online,185985-40-4 NMR,125568-73-2 Description,33097-11-9 NMR,53293-00-8 HPLC,946759-18-8 Documentation,28165-45-9 chemscene,2789-25-5 Data Sheet,1450662-30-2 Data Sheet,142356-34-1 manufacturer,1001499-95-1 web,138957-91-2 Documentation,33228-45-4 Purity ¡۸91%,214360-70-0 Technical Information,1057216-52-0 Formula,1801893-44-6 Description,334658-75-2 web,1998-66-9 MS,311-86-4 manufacturer,6291-01-6 In Stock,75884-70-7 Formula,1262397-12-5 Technical Information,41175-50-2 manufacturer,402-12-0 Documentation,927996-01-8 Description,3970-68-1 chemscene,113893-08-6 Purity ¡۹05%,461-98-3 Data Sheet,1522335-03-0 Description,499983-13-0 manufacturer,4064-06-6 Purity ¡۹09%,214342-63-9 Order Online,13669-42-6 custom synthesis,857061-44-0 HPLC,5744-80-9 supplier,275818-95-6 web,1256803-11-8 Formula,254435-23-9 site,172215-91-7 custom synthesis,56745-01-8 web,53218-26-1 Description,185220-68-2 Order Online,6334-01-6 HPLC,1455091-10-7 site,1092693-73-6 Documentation,54231-33-3 Building Blocks,374537-97-0 NMR,104901-79-3 Formula,83647-43-2 Formula,1159815-63-0 web,265981-13-3 Formula,27126-42-7 chemscene,68774-77-6 NMR,127972-00-3 In Stock,15513-48-1 custom synthesis,6587-24-2 Documentation,37669-64-0 Technical Information,6813-38-3 Building Blocks,2092312-45-1 Order Online,130309-37-4 Data Sheet,69570-83-8 web,42058-59-3 site,174565-63-0 custom synthesis,159858-21-6 Order Online,63878-73-9 web,30363-03-2 custom synthesis,362670-06-2 custom synthesis,106719-44-2 HPLC,771-97-1 supplier,381247-99-0 site,65868-63-5 Documentation,63639-61-2 Building Blocks,885952-18-1 Technical Information,88824-09-3 manufacturer,117519-07-0 Technical Information,365996-06-1 Description,25339-99-5 Technical Information,352535-84-3 MS,124668-49-1 custom synthesis,16265-11-5 Data Sheet,187344-92-9 Technical Information,5900-59-4 HPLC,1185295-39-9 MS,1343056-10-9 supplier,14997-58-1 chemscene,28562-61-0 site,2150-93-8 Data Sheet,1296209-28-3 web,165727-45-7 Data Sheet,1220028-20-5 Formula,16097-60-2 Building Blocks,84153-82-2 Order Online,87014-28-6 In Stock,1201643-59-5 chemscene,123926-62-5 Data Sheet,32993-05-8 Technical Information,860296-12-4 site,400899-84-5 NMR,89976-27-2 custom synthesis,599183-33-2 Purity ¡۹78%,7781-10-4 Formula,447-53-0 custom synthesis,1735-89-3 MS,1447963-75-8 Order Online,4815-29-6 site,3788-56-5 Order Online,916792-15-9 Technical Information,56131-46-5 Building Blocks,882679-40-5 Formula,6602-33-1 manufacturer,1000414-38-9 web,847818-55-7 Documentation,29176-55-4 HPLC,131747-63-2 Description,194995-47-6 supplier,1214337-57-1 HPLC,221295-04-1 NMR,762229-49-2 Building Blocks,870238-67-8 manufacturer,112970-44-2 custom synthesis,163451-81-8 Formula,256411-39-9 Data Sheet,1002334-12-4 manufacturer,943152-94-1 site,25021-08-3 Description,1240948-77-9 chemscene,714951-87-8 MS,3539-97-7 In Stock,3190-71-4 chemscene,219503-74-9 Building Blocks,169243-86-1 manufacturer,51985-95-6 Formula,25181-50-4 Formula,261715-71-3 Documentation,445-13-6 Description,37688-96-3 Purity ¡۱014%,934996-78-8 supplier,597551-56-9 chemscene,66131-68-8 Formula,113206-03-4 Documentation,820236-81-5 manufacturer,1260665-60-8 supplier,2380-36-1 supplier,937599-94-5 Formula,19008-71-0 Data Sheet,1010120-55-4 Description,88048-43-5 In Stock,1352144-78-5 Building Blocks,6665-97-0 Building Blocks,192214-06-5 Formula,70416-53-4 custom synthesis,99455-15-9 Technical Information,60633-26-3 Technical Information,2103-49-3 supplier,84964-24-9 manufacturer,1567892-21-0 Data Sheet,790184-33-7 manufacturer,1030012-30-6 MS,25566-00-1 Technical Information,6947-94-0 Description,91760-66-6 Technical Information,696-40-2 Documentation,1410002-81-1 NMR,345954-83-8 Data Sheet,32111-28-7 site,779-27-1 Data Sheet,4108-90-1 Formula,877-90-7 Formula,95715-87-0 In Stock,1210419-26-3 Data Sheet,174603-38-4 Data Sheet,167479-13-2 MS,55750-48-6 MS,5154-01-8 Purity ¡۱052%,66361-67-9 Description,106984-09-2 Formula,306960-74-7 site,89466-16-0 Order Online,1185297-53-3 custom synthesis,2199-58-8 web,1142400-61-0 manufacturer,62456-34-2 supplier,5147-80-8 Purity ¡۱061%,854107-53-2 Documentation,3034-48-8 chemscene,412947-54-7 Data Sheet,819058-34-9 manufacturer,1049706-73-1 MS,697300-73-5 NMR,203787-91-1 NMR,337904-92-4 chemscene,2589531-74-6 Data Sheet,66207-23-6 site,501435-91-2 manufacturer the high-FFP volume group [70]. Prior to infusion, FFP must be thawed and this is a time-consuming process. Pre-thawing of FFP may avoid this delay, but storage time is limited. Lyophilized plasma, which isSch hl et al. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2012, 20:15 http://www.sjtrem.com/content/20/1/Page 5 ofFigure 2 ROTEM-guided treatment algorithm: managing trauma-induced coagulopathy and diffuse microvascular PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26843381 bleeding (AUVA Trauma Hospital, Salzburg, Austria). The algorithm represents standard operating procedure for ROTEM-guided haemostatic therapy upon admission of trauma patients to the emergency room. In parentheses: haemostatic agents suggested for use in clinics where coagulation factor concentrates are not available. * For patients who are unconscious or known to be taking platelet inhibitor medication, Multiplate tests (adenosine diphosphate [ADP] test, arachidonic acid [ASPI] test, and thrombin receptor activating peptide-6 [TRAP] test) are also performed. ?If decreased ATIII is suspected or known, consider co-administration of ATIII. Any major improvement in APTEM parameters 4-Bromopicolinaldehyde compared to corresponding EXTEM parameters may be interpreted as a sign of hyperfibrinolysis. Only for patients not receiving TXA at an earlier stage of the algorithm. Traumatic brain injury: platelet count 80,000-100,000/l. Normal values: EXTEM/APTEM coagulation time (CT): 38-79 seconds; EXTEM/APTEM clot amplitude at 10 minutes (CA10): 43-65 mm; EXTEM/APTEM maximum lysis (ML) < 15 ; FIBTEM CA10: 7-23 mm; INTEM CT: 100-240 seconds. CA10, clot amplitude at 10 minutes; BGA, blood gas analysis; BW, body weight;.